Monday, September 12, 2011

Phytochemicals: 13 Health Benefits of Quercetin

Quercetin is a member of flavonoids, found in fruits, vegetables, leaves and grains. It is also one of antioxidants with property of protecting our body in fighting against forming of free radicals cause of mutation of cells`DNA.

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Renal function
In a study of ` Quercetin regulates organic ion transporter and uromodulin expression and improves renal function in hyperuricemic mice.` by Hu QH, Zhang X, Wang X, Jiao RQ, Kong LD. (Source from State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, People's Republic of China.) posted in PubMed, researchers found that Quercetin significantly restored oxonate-induced abnormalities of these biochemical indexes compared with normal vehicle group. Furthermore, it remarkably prevented expression changes of renal organic ion transporters and UMOD, and UMOD level alteration in hyperuricemic mice and suggested that that quercetin has the uricosuric and nephroprotective actions mediated by regulating the expression levels of renal organic ion transporters and UMOD.

2. Oxidative Stress
According to the study of `The protective effect of the flavonoids on food-mutagen-induced DNA damage in peripheral blood lymphocytes from colon cancer patients.`by Kurzawa-Zegota M, Najafzadeh M, Baumgartner A, Anderson D. (Source from Genetic and Reproductive Toxicology Group, Division of Biomedical Sciences, University of Bradford, Bradford BD7 1DP, UK.) posted in PubMed, researchers found that flavonoids (quercetin (Q) and rutin (R)) reduced oxidative stress caused by food mutagens in vitro in lymphocytes of healthy individuals and colon cancer patients. Thus, dietary supplementation with flavonoid-rich vegetables and fruits may prove very effective in protecting against oxidative stress.

3. Anti-cytogenotoxic effects
In a study of `Assessment of anti-cytogenotoxic effects of quercetin in animals treated with topotecan.`by Bakheet SA. (Source from Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. 2457, Riyadh 11451, Saudi Arabia.), posted in PubMed, researchers found that quercetin has a protective role in the abatement of topotecan-induced cyto- and genotoxicity in the bone marrow cells of mice that resides, at least in part, on its antioxidant effects. Based on the data presented, strategies can be developed to decrease the topotecan-induced bone marrow suppression and secondary malignancy in cancer patients and medical personnel exposing to topotecan.

4. Leukemias
According to the study of `Quercetin-induced apoptosis involves increased hTERT enzyme activity of leukemic cells.`by Avci CB, Yilmaz S, Dogan ZO, Saydam G, Dodurga Y, Ekiz HA, Kartal M, Sahin F, Baran Y, Gunduz C. (Source from School of Medicine, Ege University, Izmir, Turkey.), posted in PubMed, researchers found that The effects of quercetin on telomerase enzyme activity were shown by hTERT Quantification Kit. Our results demonstrated that quercetin has antiproliferative and apoptotic effects on T-cell acute lymphoblastic leukemia (ALL), acute promyelocytic leukemia, and chronic myeloid leukemia (CML) cells. We also showed for the first time by this study that quercetin suppresses the activity of telomerase in ALL and CML cells. The results of this study show the importance of quercetin for its therapeutic potential in treatment of leukemias.

5. Free radical scavenger
In a study of `Dietary chromones as antioxidant agents-the structural variable.`by Dias MM, Machado NF, Marques MP. (Source from Research Unit "Molecular Physical Chemistry", University of Coimbra, Portugal.), posted in PubMed, researchers found that from the eighteen tested compounds, three-fisetin, luteolin and quercetin-are shown to act as effective antiradicals. Consistent structure-activity relationships (SARs) were established regarding the antioxidant role of this type of chromone-based system.

6. Adjuvant cancer therapy
In a study of `The flavonoid quercetin in disease prevention and therapy: Facts and fancies.`by
Russo M, Spagnuolo C, Tedesco I, Bilotto S, Russo GL. (Source from Institute of Food Sciences, National Research Council, 83100 Avellino, Italy.), posted in PubMed, researchers found that The ameliorating effect of quercetin administration can be extended to other chronic inflammatory disorders but only if supplementation occurs in patients. Quercetin can be considered the prototype of a naturally-occurring chemopreventive agent because of its key roles in triggering the "hallmarks of cancer". However, several critical points must be taken into account when considering the potential therapeutic use of this molecule: (1) pharmacological versus nutraceutical doses applied, (2) specificity of its mechanism of action compared to other phytochemicals, and (3) identification of "direct" cellular targets. The design of specific clinical trials is extremely warranted to depict possible applications of quercetin in adjuvant cancer therapy.

7. Anti-Inflammatory
According to the study of `Antioxidant and Anti-Inflammatory Activities of Quercetin 7-O-β-D-Glucopyranoside from the Leaves of Brasenia schreberi.`by Legault J, Perron T, Mshvildadze V, Girard-Lalancette K, Perron S, Laprise C, Sirois P, Pichette A. (Source from Laboratory for Analysis and Separation of Plant Species (LASEVE), Université du Québec à Chicoutimi , Chicoutimi, Québec, Canada.), posted in PubMed, researchers found that some flavonoids have been reported to possess beneficial effects in cardiovascular and chronic inflammatory diseases associated with overproduction of nitric oxide. Quercetin-7-O-β-D-glucopyranoside possesses anti-inflammatory activity, inhibiting expression of inducible nitric oxide synthase and release of nitric oxide by lipopolysaccharide-stimulated RAW 264.7 macrophages in a dose-dependent manner. Quercetin-7-O-β-D-glucopyranoside also inhibited overexpression of cyclooxygenase-2 and granulocyte macrophage-colony-stimulating factor.

8. Cholesterol atherosclerosis
In a study of `Correction of lipid peroxidation and antioxidant system by bioflavonoids during modeling of rabbit cholesterol atherosclerosis.`[Article in Ukrainian], [No authors listed], posted in PubMed, researchers found that we showed that under hypercholesterolemia, the concentration of malone dialdehyde in myocardial tissue in rabbits is significantly increased, while administration of bioflavonoids (quercetin, corvitin) decreased the concentration of malone dialdehyde by 38.3%. Furthermore, corvitin caused activating effects on antioxidant enzymes superoxide dismutase and catalase in cardiac tissue. Our data suggest that bioflavonoids are able to suppress lipid peroxidation and prevent the decrease of antioxidant enzymes activity in rabbits with cholesterol-rich diet induced atherosclerosis.

9. Anti-tumour adjuvant agent
According to the study of ` Radiofrequency ablation combined with liposomal quercetin to increase tumour destruction by modulation of heat shock protein production in a small animal model.`by Yang W, Ahmed M, Tasawwar B, Levchenko T, Sawant RR, Collins M, Signoretti S, Torchilin V, Goldberg SN. (Source from Minimally Invasive Tumor Therapies Laboratory, Department of Radiology, Beth Israel Deaconess Medical Center/Harvard Medical School , Boston, MA , USA.), posted in PubMed, researchers found that Suppression of HSP production using adjuvant liposomal quercetin can increase apoptosis and improve RF ablation-induced tumour destruction. Further increases in tumour coagulation can be seen including an additional anti-tumour adjuvant agent such as liposomal doxorubicin.

10. Anticancer activity
In the study of `Antiproliferative activity and standardization of Tecomella undulata bark extract on K562 cells.`by Ravi A, Mallika A, Sama V, Begum AS, Khan RS, Reddy BM. (Source from G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad-500 028, AP, India.) posted in PubMed, researchers found that The investigation clearly demonstrated the potential antitumor effect of CTUB, thereby validating the traditional claim. Quercetin, known to have anticancer activity is being reported and quantified for the first time from the bark of Tecomella undulata.

11. Antimicrobial and cytotoxic activities
According to the study of `Antimicrobial and cytotoxic activities of leaves, twigs and stem bark of Scutia buxifolia Reissek.`by Boligon AA, Janovik V, Frohlich JK, Spader TB, Forbrig Froeder AL, Alves SH, Athayde ML. (Source from a Phytochemical Research Laboratory, Department of Industrial Pharmacy , Federal University of Santa Maria , Build 26, room 1115 , Santa Maria , CEP 97105-900 , Brazil.), posted in PubMed, researchers found that quercitrin, isoquercitrin and rutin were identified by HPLC and may be partially responsible for the antimicrobial activities observed. This study reports for the first time the antimicrobial and cytotoxic activities of S. buxifolia leaves, twigs and stem bark.

12. Visceral Adipose Tissue
According to the study of `Influence of Quercetin-rich Onion Peel Extracts on Adipokine Expression in the Visceral Adipose Tissue of Rats.`by Kim OY, Lee SM, Do H, Moon J, Lee KH, Cha YJ, Shin MJ. (Source from Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Republic of Korea.), posted in PubMed, researchers found that quercetin-rich onion peel extract supplementation influenced adipokine expressions, particularly from mesenteric fat, addressing the modulatory effect of this substance on obesity-induced inflammation.

13. Hepatotoxicity
In a study of `Hepatoprotective activity of quercetin against acrylonitrile-induced hepatotoxicity in rats. by Abo-Salem OM, Abd-Ellah MF, Ghonaim MM. (Source from Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt., posted in PubMed, researchers found that Pretreatment with quercetin (70 mg/kg/day/6 weeks) and its coadministration with acrylonitrile prevented acrylonitrile-induced alterations in hepatic lipid peroxides and enzymatic antioxidants as well as serum aminotransferases and bilirubin. Histopathological findings supported the biochemical results. We suggest that querectin possess hepatoprotective effect against acrylonitrile-induced hepatotoxicity through its antioxidant activity. © 2011 Wiley Periodicals, Inc. J Biochem Mol Toxicol 00:1-7 2011; View this article online at DOI 10.1002/jbt.20406.

14. Etc.

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